DRAFT NTP BRIEF ON BISPHENOL A [ CAS NO . 80 - 05 - 7 ] April 14 , 2008

Biodegradation or metabolism of bisphenol A: from microorganisms to mammals.

Bisphenol A (BPA; 2,2-bis(4-hydroxyphenyl)propane; CAS Registry No. 80-05-7) is one of endocrine disruptors and is made by combining acetone and phenol. BPA can be metabolized by extensive organisms. In this review these BPA biodegradations or metabolisms by many organisms from microorganisms to mammals were referred. Though the metabolites of BPA can enhance estrogenicity or toxicity, generall...

Bisphenol A: Where to Now?

volume 117 | number 3 | March 2009 • Environmental Health Perspectives Recently, Time magazine published an article titled “The Year in Medicine: From A to Z” (Park et al. 2008). The letter “B” was represented by the controversy over bisphenol A, a ubiquitous chemical used in polycarbonate and polyvinyl chloride plastics and epoxy resins and found in the urine of > 90% of Americans. The debate ...

Guest Editorial: NTP: New Initiatives, New Alignment

has for nearly 30 years led the effort to apply the science of toxicology to the protection of public health. In June 2007 I became the Associate Director of the NTP. I accepted this challenge with enthusiasm and pledged to a) maintain our traditional areas of strength in toxicology research and testing; b) accelerate our efforts to fulfill the goals set forth in A National Toxicology Program f...

Draft Assessment of Bisphenol a for Use in Food Contact Applications

Effects of nifedipine on diastolic function during brief periods of flow-limiting ischemia in the conscious dog.

To determine the contribution of transsarcolemmal calcium flux to abnormal diastolic function produced by brief periods of flow-limiting ischemia and reperfusion, we evaluated early and late diastolic function during transient coronary occlusion and reperfusion before and during administration of intravenous nifedipine (NIF) (10 +/- 1 microgram/kg/min) in nine preinstrumented conscious dogs. We...